3 results
Maternal tobacco smoking in pregnancy and children’s socio-emotional development at age 5: The EDEN mother-child birth cohort study
- M. Melchior, R. Hersi, J. van der Waerden, B. Larroque, M.-J. Saurel-Cubizolles, A. Chollet, C. Galéra
-
- Journal:
- European Psychiatry / Volume 30 / Issue 5 / July 2015
- Published online by Cambridge University Press:
- 15 April 2020, pp. 562-568
-
- Article
- Export citation
-
Background
There is debate as to whether maternal tobacco use in pregnancy is related to offspring behaviour later on. We tested this association examining multiple aspects of children's behaviour at age 5 and accounting for parental smoking outside of pregnancy, as well as child and family characteristics.
MethodsData come from a prospective community based birth cohort study (EDEN; n = 1113 families in France followed since pregnancy in 2003–2005 until the child's 5th birthday). Maternal tobacco use in pregnancy was self-reported. Children's socio-emotional development (emotional symptoms, conduct problems, symptoms of hyperactivity/inattention, peer relationship problems, prosocial behaviour) was assessed by mothers using the Strengths and Difficulties Questionnaire (SDQ) at age 5 years. Logistic regression analyses controlled for Inverse Probability Weights (IPW) of maternal tobacco use calculated based on study center, children's characteristics (sex, premature birth, low birth weight, breastfeeding), maternal characteristics (age at the child's birth, psychological difficulties and alcohol use in pregnancy, post-pregnancy depression, and smoking), paternal smoking in and post-pregnancy, parental educational attainment, family income, parental separation, and maternal negative life events.
ResultsMaternal smoking in pregnancy only predicted children's high symptoms of hyperactivity/inattention (sex and study center-adjusted ORs: maternal smoking in the 1st trimester: 1.95, 95%CI: 1.13–3.38; maternal smoking throughout pregnancy: OR = 2.11, 95%CI: 1.36–3.27). In IPW-controlled regression models, only children of mothers who smoked throughout pregnancy had significantly elevated levels of hyperactivity/inattention (OR = 2.20, 95%CI: 1.21–4.00).
ConclusionsMaternal tobacco smoking in pregnancy may contribute directly or through epigenetic mechanisms to children's symptoms of hyperactivity/inattention.
Response profiles of dairy cows to a single 24-h milking interval in relation with milk proteolysis, udder expansion and immune traits
- C. Charton, H. Larroque, S. Pochet, P. Germon, G. Lequeux, J. Guinard-Flament
-
- Article
- Export citation
-
An extended milking interval of 24 h (24-h milking interval (24h-MI)) constitutes the acute phase of cow adaptation to once-daily milking (ODM). A recent trial including 724 24h-MI challenges demonstrated that milk yield responses to this acute phase of ODM are highly variable (from+22% to −52% of milk yield when switching to the 24h-MI, mean=−25.3%) and that factors such as stage of lactation parity and milk yield level influenced cows’ responses but did not account for all individual variability. Additional traits related to physiological, immune and behavioural adaptation were measured on a subset (96 observations) of this data set. This study aimed to determine (1) the relationship of these traits with cows’ milk yield responses, (2) their ability – combined with previously identified traits – to help predict milk yield responses to 24h-MI (adaptive profiles). The 24h-MI challenge consisted of three successive periods: one control week of twice-daily milking (cTDM), one single day of 24h-MI and then 13 days of TDM (pTDM). Milk yield responses to the 24h-MI (corrected for effects of stage of lactation, parity, milk yield level and milk yield) were related to physiological traits measured during cTDM (milk flow rate, presence or absence of interleukin-8) and to their changes during the 24h-MI (absolute increase in milk flow rate and relative udder distension). Analysis of associations between milk yield responses, stage of lactation, parity, milk yield level, proteolysis, udder expansion and immune traits found three adaptive cow profile clusters. Cows in cluster 1 had a less compliant udder than cows in cluster 2, and they lost more milk during the 24h-MI than cluster-2 and cluster-3 cows. After resuming twice daily-milking (TDM), cluster-2 cows fully recovered the milk they had lost during the 24h-MI. On the opposite, cluster-3 cows did not recover the milk they lost, likely due to udder inflammation during cTDM, as suggested by elevated concentrations of interleukin-8 in their milk. These results combining new traits with stage of lactation, parity and milk yield level constitute a first step towards predicting individual cow responses to a 24h-MI.
Active and recent deformation at the Southern Alps – Ligurian basin junction
- C. Larroque, N. Béthoux, E. Calais, F. Courboulex, A. Deschamps, J. Déverchère, J.-F. Stéphan, J.-F. Ritz, E. Gilli
-
- Journal:
- Netherlands Journal of Geosciences / Volume 80 / Issue 3-4 / December 2001
- Published online by Cambridge University Press:
- 01 April 2016, pp. 255-272
-
- Article
-
- You have access Access
- Export citation
-
The Southern Alps – Ligurian basin junction is one of the most active seismic areas in Western Europe countries. The topographic and the structural setting of this region is complex because of (i) its position between the high topography of the Southern Alps and the deep, narrow Ligurian oceanic basin, and (ii) the large number of structures inherited from the Alpine orogeny. Historical seismicity reveals about twenty moderate-size earthquakes (up to M=6.0), mostly distributed along the Ligurian coast and the Vésubie valley. A recent geodetic experiment shows a significant strain rate during the last 50 years in the area between the Argentera massif and the Mediterranean coastline. Results of this experiment suggest a N-S shortening of about 2-4 mm/yr over the network, this shortening direction is consistent with the seismological (P-axes of earthquakes) and the microtectonic data. The Pennic front (E-NE of the Argentera massif) and the northern Ligurian margin are the most seismically active areas. In the Nice arc and in the Argentera massif, some seismic lineaments correspond to faults identified in the field (such as theTaggia-Saorge fault or the Monaco-Sospel fault). In the western part of the Alpes Maritimes, no seismic activity is recorded in the Castellane arc. In the field, geological evidence, such as offsets of recent alluvial sediments, recent fault breccia, speleothem deformations, radon anomalies and others indicates recent deformation along these faults. Nevertheless, to this date active fault scarps have not been identified: this probably results from a relatively high erosion rate versus deformation rate and from the lack of Quaternary markers. We also suspect the presence of two hidden active faults, one in the lower Var valley (Nice city area) and the other one at the base of the Argentera crustal thrust-sheet. Offshore, along the northern Ligurian margin, the seismic reflection data shows traces of Quaternary extensional deformation, but the accuracy of the data does not yet allow the construction of a structural map nor does it allow the determination of the continuity between the offshore and onshore structures. From these data set we propose a preliminary map of 11 active faults and we discuss the questions which remain unsolved in the perspective of seismic hazard evaluations.